Subchronic heavy metal and alcohol treatment in rats

Changes in the somatosensory evoked cortical activity

Anita Lukács, Zsuzsanna Lengyel, L. Institóris, A. Szabó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Young adult male Wistar rats were treated, by gavage, with 80 or 320 mg/kg Pb2+ (lead acetate), 0.4 or 1.6 mg/kg Hg2+ (mercuric chloride) or both by combining the lower doses. For combination with alcohol, ethanol was added to the rats' drinking water in 5 v/v %. After 12 weeks of treatment, electrophysiological recording was made from the somatosensory cortex in urethane anaesthesia. Evoked potentials obtained by stimulation of the whiskers were recorded. Both metals, and alcohol alone, increased significantly the latency of the evoked response. Alcohol seemed to abolish the effect of Pb, but not of Hg. Fatigue, calculated form the response amplitude, was increased by Pb and Hg treatment and this effect of Hg was reduced by ethanol. Evoked activity and its dynamic characteristics were sensitive to the complex neurotoxic effect induced in the rats and can provide a basis for developing functional markers.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalActa Biologica Hungarica
Volume58
Issue number3
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Heavy Metals
Rats
alcohol
heavy metals
alcohols
Alcohols
heavy metal
ethanol
rats
Ethanol
lead acetate
urethane
mercuric chloride
Vibrissae
Mercuric Chloride
Somatosensory Cortex
evoked potentials
Urethane
Bioelectric potentials
young adults

Keywords

  • Alcohol
  • Combination
  • Lead
  • Mercury
  • Neurotoxicity
  • Rat

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Subchronic heavy metal and alcohol treatment in rats : Changes in the somatosensory evoked cortical activity. / Lukács, Anita; Lengyel, Zsuzsanna; Institóris, L.; Szabó, A.

In: Acta Biologica Hungarica, Vol. 58, No. 3, 09.2007, p. 259-267.

Research output: Contribution to journalArticle

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