The calcium accumulating capacity of neurohypophysial axon terminals stimulated by the intravenous injection of hypertonic saline has been studied by using light and electron microscopic histoehemical methods and X-ray microanalysis. In the stimulated neurosecretory terminals Ca++ containing granules appeared in the mitochondria. Smaller granules of similar morphological appearance occurred in the smooth endoplasmic reticulum as well. It is suggested that the mitochondria and the smooth endoplasmic reticulum are intimately involved in the regulation of the intraaxonal free calcium level during the process of vasopressin secretion.
ASJC Scopus subject areas
- Cell Biology