The oxygen consumption, subcellular distribution of hexokinase were studied in normal and leukemic spleen cells of AKR mice. High mitochondrial-bound hexokinase activity and O2-consumption were detected in fetal state, in leukemic or BPV-induced lymphoproliferative conditions and after spermine incubation of normal spleen cells. After ConA-treatment, however, all of the hexokinase was found in cytoplasmic fraction and O2-uptake was strongly decreased. Studies on respiration of mitochondria isolated from normal and leukemic cells supported the role of mitochondrial-bound hexokinase in elevated O2-consumption of leukemic cells.
|Number of pages||6|
|Publication status||Published - 1988|
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