Subacute toxicity assessment of water disinfection byproducts on zebrafish

Gergely Rácz, Zsolt Csenki, Róbert Kovács, Árpád Hegyi, F. Baska, László Sujbert, Ivett Zsákovics, Renáta Kis, Ryan Gustafson, B. Urbányi, B. Szende

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Disinfection of raw water is essential to the production of drinking water. However, by-products of disinfection may exert toxic effects. The potential toxic effects of two of these compounds, 4-ethylbenzaldehyde (EBA) and 2,4-difluoroaniline (DFA) were investigated using the zebrafish (Danio rerio) model. The two compounds, dissolved, were introduced in duplicate aquariums containing zebrafish in two different concentrations based on LC50 values. The aquarium water containing EBA or DFAwas changed every 96 h throughout the 3 months of treatment. Behavior of the fish in each replicate was inspected twice daily. In course of treatment with both concentrations, fish exposed to DFA displayed behavior associated with visible anxiety, while EBA treated were lethargic and did not evade capture. Application of both concentrations of each component into the aquarium water resulted in dystrophic lesions in the liver, kidney and skin of the fish while preneoplastic lesions and tumors were not observed.

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalPathology and Oncology Research
Volume18
Issue number3
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Disinfection
Zebrafish
Fishes
Poisons
Water
Drinking Water
Anxiety
Kidney
Skin
Liver
Neoplasms
2,4-difluoroaniline

Keywords

  • 2,4-Difluoroaniline
  • 4-Ethylbenzaldehyde
  • Water disinfection byproducts
  • Zebrafish

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Subacute toxicity assessment of water disinfection byproducts on zebrafish. / Rácz, Gergely; Csenki, Zsolt; Kovács, Róbert; Hegyi, Árpád; Baska, F.; Sujbert, László; Zsákovics, Ivett; Kis, Renáta; Gustafson, Ryan; Urbányi, B.; Szende, B.

In: Pathology and Oncology Research, Vol. 18, No. 3, 07.2012, p. 579-584.

Research output: Contribution to journalArticle

Rácz, G, Csenki, Z, Kovács, R, Hegyi, Á, Baska, F, Sujbert, L, Zsákovics, I, Kis, R, Gustafson, R, Urbányi, B & Szende, B 2012, 'Subacute toxicity assessment of water disinfection byproducts on zebrafish', Pathology and Oncology Research, vol. 18, no. 3, pp. 579-584. https://doi.org/10.1007/s12253-011-9479-3
Rácz, Gergely ; Csenki, Zsolt ; Kovács, Róbert ; Hegyi, Árpád ; Baska, F. ; Sujbert, László ; Zsákovics, Ivett ; Kis, Renáta ; Gustafson, Ryan ; Urbányi, B. ; Szende, B. / Subacute toxicity assessment of water disinfection byproducts on zebrafish. In: Pathology and Oncology Research. 2012 ; Vol. 18, No. 3. pp. 579-584.
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