Studying the genetic predisposing factors in the pathogenesis of acne vulgaris

Kornélia Szabó, L. Kemény

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Acne is one of the most common dermatologic diseases in the developed regions of the world, affecting a large percentage of the population. Despite the great improvement in the number and quality of studies of the molecular etiology of this disease in the past 3 decades, the detailed molecular pathogenesis and the cause of the large individual variations in severity of skin symptoms remain unknown. The roles of genetic inheritance and special genetic susceptibility and protective factors have been suggested for over 100 years, but their identification and determination started only in the 1990s. To date, only a small number of genetic polymorphisms affecting the expression and/or function of a handful of genes have been investigated. This review surveys the major findings of the classic and molecular genetic studies that have been conducted in this field, draws conclusions, and indicates how the available data help our current understanding of the pathogenesis of this common skin disease.

Original languageEnglish
Pages (from-to)766-773
Number of pages8
JournalHuman Immunology
Volume72
Issue number9
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Acne Vulgaris
Causality
Genetic Polymorphisms
Genetic Predisposition to Disease
Skin Diseases
Molecular Biology
Skin
Population
Genes
Surveys and Questionnaires
Protective Factors

Keywords

  • Acne vulgaris
  • Cross-sectional studies
  • Molecular genetic studies
  • Population-based studies
  • Twin studies

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Studying the genetic predisposing factors in the pathogenesis of acne vulgaris. / Szabó, Kornélia; Kemény, L.

In: Human Immunology, Vol. 72, No. 9, 09.2011, p. 766-773.

Research output: Contribution to journalArticle

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