Study on the role of maternal sex steroid production and metabolism in the embryotoxicity of para-xylene

György Ungváry, Bertalan Varga, Edit Horváth, E. Tátrai, Gábor Folly

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

CFY rats were exposed to inhalation of clean air or air containing para-xylene (3000 mg/m3) on the 10th, and 9th and 10th days of gestation. Uterine and ovarian venous blood flow, fetal weight, ovarian progesterone and 17β-oestradiol secretion, and the progesterone and 17β-oestradiol level of peripheral blood (uterine and femoral veins) were measured on the 11th day of gestation. Exposure to para-xylene decreased the weight of the fetuses and the progesterone and 17β-oestradiol levels of peripheral blood, but it did not influence the uterine and ovarian venous outflow and the ovarian progesterone and 17β-oestradiol secretion rate. It is concluded that para-xylene, by inducing the hepatic monooxygenase system, facilitates the biotransformation of progesterone and 17β-oestradiol, which is metabolized by this enzyme system. The decrease in the sex hormone level of peripheral blood is supposed to play a role in the embryotoxicity (retarding and lethal effects) of para-xylene.

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalToxicology
Volume19
Issue number3
DOIs
Publication statusPublished - 1981

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Metabolism
Progesterone
Estradiol
Steroids
Mothers
Blood
Air
Pregnancy
Fetal Weight
Femoral Vein
Gonadal Steroid Hormones
Biotransformation
Mixed Function Oxygenases
Inhalation
Rats
Fetus
4-xylene
Weights and Measures
Liver
Enzymes

ASJC Scopus subject areas

  • Toxicology

Cite this

Study on the role of maternal sex steroid production and metabolism in the embryotoxicity of para-xylene. / Ungváry, György; Varga, Bertalan; Horváth, Edit; Tátrai, E.; Folly, Gábor.

In: Toxicology, Vol. 19, No. 3, 1981, p. 263-268.

Research output: Contribution to journalArticle

Ungváry, György ; Varga, Bertalan ; Horváth, Edit ; Tátrai, E. ; Folly, Gábor. / Study on the role of maternal sex steroid production and metabolism in the embryotoxicity of para-xylene. In: Toxicology. 1981 ; Vol. 19, No. 3. pp. 263-268.
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