Study on the release of chlorhexidine base and salts from different liquid crystalline structures

Edit Farkas, Dorottya Kiss, R. Zelkó

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The aim of this study was to investigate the influence of two types of chlorhexidine species, chlorhexidine base and its salts, on the physico-chemical features of liquid crystalline systems and on drug transport through lipophilic membranes. A non-ionic surfactant, Synperonic A7 (PEG7-C13-15) was selected for the preparation of the liquid crystalline systems. Mixtures of different ratios of Synperonic A7 and water were prepared. The liquid crystalline systems were characterized using polarizing microscopy and dynamic oscillatory test. Membrane transport was also examined. The addition of chlorhexidine species to the liquid crystalline system modified the structure of the liquid crystalline system. As a result of the changes of liquid crystalline structures, the drug release of various types of chlorhexidine could be also modified. The combination of the base and salt forms of the drug in one dosage form could eliminate the drug release changes from liquid crystalline systems of dynamically changeable structures.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume340
Issue number1-2
DOIs
Publication statusPublished - Aug 1 2007

Fingerprint

Chlorhexidine
Salts
Membranes
Dosage Forms
Surface-Active Agents
Pharmaceutical Preparations
Microscopy
Water
Drug Liberation

Keywords

  • Chlorhexidine
  • Chlorhexidine digluconate
  • Drug release
  • Dynamic oscillatory test
  • Lamellar and hexagonal structure
  • Liquid crystals
  • Polarizing microscopy

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Study on the release of chlorhexidine base and salts from different liquid crystalline structures. / Farkas, Edit; Kiss, Dorottya; Zelkó, R.

In: International Journal of Pharmaceutics, Vol. 340, No. 1-2, 01.08.2007, p. 71-75.

Research output: Contribution to journalArticle

@article{5516200def7e41d8adf9895002216e98,
title = "Study on the release of chlorhexidine base and salts from different liquid crystalline structures",
abstract = "The aim of this study was to investigate the influence of two types of chlorhexidine species, chlorhexidine base and its salts, on the physico-chemical features of liquid crystalline systems and on drug transport through lipophilic membranes. A non-ionic surfactant, Synperonic A7 (PEG7-C13-15) was selected for the preparation of the liquid crystalline systems. Mixtures of different ratios of Synperonic A7 and water were prepared. The liquid crystalline systems were characterized using polarizing microscopy and dynamic oscillatory test. Membrane transport was also examined. The addition of chlorhexidine species to the liquid crystalline system modified the structure of the liquid crystalline system. As a result of the changes of liquid crystalline structures, the drug release of various types of chlorhexidine could be also modified. The combination of the base and salt forms of the drug in one dosage form could eliminate the drug release changes from liquid crystalline systems of dynamically changeable structures.",
keywords = "Chlorhexidine, Chlorhexidine digluconate, Drug release, Dynamic oscillatory test, Lamellar and hexagonal structure, Liquid crystals, Polarizing microscopy",
author = "Edit Farkas and Dorottya Kiss and R. Zelk{\'o}",
year = "2007",
month = "8",
day = "1",
doi = "10.1016/j.ijpharm.2007.03.038",
language = "English",
volume = "340",
pages = "71--75",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Study on the release of chlorhexidine base and salts from different liquid crystalline structures

AU - Farkas, Edit

AU - Kiss, Dorottya

AU - Zelkó, R.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - The aim of this study was to investigate the influence of two types of chlorhexidine species, chlorhexidine base and its salts, on the physico-chemical features of liquid crystalline systems and on drug transport through lipophilic membranes. A non-ionic surfactant, Synperonic A7 (PEG7-C13-15) was selected for the preparation of the liquid crystalline systems. Mixtures of different ratios of Synperonic A7 and water were prepared. The liquid crystalline systems were characterized using polarizing microscopy and dynamic oscillatory test. Membrane transport was also examined. The addition of chlorhexidine species to the liquid crystalline system modified the structure of the liquid crystalline system. As a result of the changes of liquid crystalline structures, the drug release of various types of chlorhexidine could be also modified. The combination of the base and salt forms of the drug in one dosage form could eliminate the drug release changes from liquid crystalline systems of dynamically changeable structures.

AB - The aim of this study was to investigate the influence of two types of chlorhexidine species, chlorhexidine base and its salts, on the physico-chemical features of liquid crystalline systems and on drug transport through lipophilic membranes. A non-ionic surfactant, Synperonic A7 (PEG7-C13-15) was selected for the preparation of the liquid crystalline systems. Mixtures of different ratios of Synperonic A7 and water were prepared. The liquid crystalline systems were characterized using polarizing microscopy and dynamic oscillatory test. Membrane transport was also examined. The addition of chlorhexidine species to the liquid crystalline system modified the structure of the liquid crystalline system. As a result of the changes of liquid crystalline structures, the drug release of various types of chlorhexidine could be also modified. The combination of the base and salt forms of the drug in one dosage form could eliminate the drug release changes from liquid crystalline systems of dynamically changeable structures.

KW - Chlorhexidine

KW - Chlorhexidine digluconate

KW - Drug release

KW - Dynamic oscillatory test

KW - Lamellar and hexagonal structure

KW - Liquid crystals

KW - Polarizing microscopy

UR - http://www.scopus.com/inward/record.url?scp=34447288265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447288265&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2007.03.038

DO - 10.1016/j.ijpharm.2007.03.038

M3 - Article

VL - 340

SP - 71

EP - 75

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -