Study on the course of cryptosporidium baileyi infection in chickens treated with interleukin-1 or indomethacin

S. Hornok, Z. Széll, Tatjana A. Shibalova, I. Varga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects exerted by human recombinant interleukin-1β (hrIL-1β) and the prostaglandin inhibitor indomethacin on the course of Cryptosporidium baileyi infection in chickens were studied. Daily oocyst shedding was monitored by a quantitative method throughout the experiment. Humoral immune response to C. baileyi was assessed by ELISA at 3 weeks of age while the level of cellular immune response to phytohaemagglutinin-P (PHA-P) by a skin test at 23 days of age. Patenteral application of hrIL-1β decreased oocyst shedding to 62%, but the infection ran a similar course in treated and control birds. The PHA-P skin test demonstrated increased cellular immune reaction in chickens receiving IL-1β, but there was no significant difference in the humoral responses of the two groups as detected by ELISA. On the other hand, indomethacin mixed to the feed lessened oocyst shedding to 13.7% and also shortened its duration. Immunological parameters as reflected by PHA-P skin test and ELISA results indicated enhanced cellular but unaltered humoral immune response. These data suggest that the systemic application of interleukin-1 can induce partial protection against C. baileyi in chickens and that prolonged, abundant oocyst shedding is due to an indomethacin-sensitive immunodepression via the prostaglandin pathway.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalActa Veterinaria Hungarica
Volume47
Issue number2
Publication statusPublished - 1999

Fingerprint

Cryptosporidium baileyi
Cryptosporidium
Oocysts
indomethacin
interleukin-1
Interleukin-1
oocysts
Indomethacin
skin tests
Chickens
phytohemagglutinin
Skin Tests
humoral immunity
chickens
Enzyme-Linked Immunosorbent Assay
enzyme-linked immunosorbent assay
Humoral Immunity
Infection
infection
prostaglandins

Keywords

  • Chicken
  • Cryptosporidium baileyi
  • Cytokine
  • Indomethacin
  • Interleukin-1

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Study on the course of cryptosporidium baileyi infection in chickens treated with interleukin-1 or indomethacin. / Hornok, S.; Széll, Z.; Shibalova, Tatjana A.; Varga, I.

In: Acta Veterinaria Hungarica, Vol. 47, No. 2, 1999, p. 207-216.

Research output: Contribution to journalArticle

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