Study on the biological half-life and organ-distribution of tritiated lysine-vasopressin in Brattleboro rats

F. Laczi, F. László, G. Kéri, I. Teplan

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2 Citations (Scopus)

Abstract

The biological half-life and organ-distribution of tritiated lysine-vasopressin were determined in R-Amsterdam rats, and in homozygous and heterozygous Brattleboro rats with hereditary central diabetes insipidus. It was found that the biological half-life of the tritiated lysin-vasopressin in the Brattleboro rats did not differ significantly from that found in the R-Amsterdam rats. The highest radioactivities were observed in the neuro-and adenohypophyses and in the kidneys of both the R-Amsterdam and the Brattleboro rats. The accumulation of tritiated LVP was higher in the small intestine of the Brattleboro rats than in that of the R-Amsterdam animals. The results have led to the conclusion that the accelerated elimination of vasopressin and its pathologic organ-accumulation are probably not involved in the water metabolism disturbance of Brattleboro rats with hereditary hypothalamic diabetes insipidus.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalActa Physiologica Academiae Scientiarum Hungaricae
Volume55
Issue number2
Publication statusPublished - 1980

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Lypressin
Brattleboro Rats
Half-Life
Vasopressins
Neurogenic Diabetes Insipidus
Diabetes Insipidus
Anterior Pituitary Gland
Radioactivity
Small Intestine
Kidney
Water

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "The biological half-life and organ-distribution of tritiated lysine-vasopressin were determined in R-Amsterdam rats, and in homozygous and heterozygous Brattleboro rats with hereditary central diabetes insipidus. It was found that the biological half-life of the tritiated lysin-vasopressin in the Brattleboro rats did not differ significantly from that found in the R-Amsterdam rats. The highest radioactivities were observed in the neuro-and adenohypophyses and in the kidneys of both the R-Amsterdam and the Brattleboro rats. The accumulation of tritiated LVP was higher in the small intestine of the Brattleboro rats than in that of the R-Amsterdam animals. The results have led to the conclusion that the accelerated elimination of vasopressin and its pathologic organ-accumulation are probably not involved in the water metabolism disturbance of Brattleboro rats with hereditary hypothalamic diabetes insipidus.",
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AU - Laczi, F.

AU - László, F.

AU - Kéri, G.

AU - Teplan, I.

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