Study on the biological half-life and organ-distribution of tritiated lysine-vasopressin in Brattleboro rats

F. Laczi, F. A. Laszlo, Gy Keri, I. Teplan

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Abstract

The biological half-life and organ-distribution of tritiated lysine-vasopressin were determined in R-Amsterdam rats, and in homozygous and heterozygous Brattleboro rats with hereditary central diabetes insipidus. It was found that the biological half-life of the tritiated lysin-vasopressin in the Brattleboro rats did not differ significantly from that found in the R-Amsterdam rats. The highest radioactivities were observed in the neuro-and adenohypophyses and in the kidneys of both the R-Amsterdam and the Brattleboro rats. The accumulation of tritiated LVP was higher in the small intestine of the Brattleboro rats than in that of the R-Amsterdam animals. The results have led to the conclusion that the accelerated elimination of vasopressin and its pathologic organ-accumulation are probably not involved in the water metabolism disturbance of Brattleboro rats with hereditary hypothalamic diabetes insipidus.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalActa physiologica Academiae Scientiarum Hungaricae
Volume55
Issue number2
Publication statusPublished - Dec 1 1980

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ASJC Scopus subject areas

  • Physiology

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