A nitrogén-monoxid metabolizmus változásának vizsgálata diabéteszes állatmodellen

Translated title of the contribution: Study on the altered nitric oxide metabolism in experimental diabetes

Research output: Contribution to journalArticle

Abstract

Decreased biological action of nitric oxide (NO) and increased oxidative stress are established to be involved in the development of endothelium dysfunction, early sign of diabetic angiopathy. In the present study, increased nitric oxide synthase (NOS) enzyme activity in the aorta and decreased activity in the kidney tissue of streptozotocin-induced diabetic rats has been found in the early phase of the disease. Augmentation of oxidative transformation of NO in the kidney and heart of the diabetic animals has been demonstrated by the measurement of the stable end-products of NO and other reactive nitrogen species. Insulin treatment was found effective to reduce the intensified oxidative metabolism of NO without increasing its production. Reduced biological effects of NO observed in endothelial dysfunction, is thus probably the consequence of its increased oxidative inactivation.

Translated title of the contributionStudy on the altered nitric oxide metabolism in experimental diabetes
Original languageHungarian
Pages (from-to)19-23
Number of pages5
JournalActa pharmaceutica Hungarica
Volume76
Issue number1
Publication statusPublished - Mar 24 2006

ASJC Scopus subject areas

  • Pharmaceutical Science

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