Study on steroidal oximinoethers: Synthesis and stereostructure by NMR spectroscopy

Pál Sohár, András Bodor, Róbert Schwartz

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4 Citations (Scopus)

Abstract

The condensation of O-substituted hydroxylamines with conjugated 3-oxo- 4-en steroids results in a mixture of syn-anti configurations. Syn-anti ratios are influenced by sterical hindrance between the oximino substituents (e.g. O-benzyl) and the steroidal skeleton. Stereostructures and isomeric ratios were proved by detailed 1H and 13C NMR studies and also by using 2D-COSY, 2D-HSC, DEPT, 2D-COLOC and DNOE measurements.

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalSteroids
Volume64
Issue number4
DOIs
Publication statusPublished - Apr 1999

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Keywords

  • DNOE
  • NMR studies
  • O-Benzyloximino-4-en-steroids
  • Syn-anti configurations of oximino ethers
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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