Embryo cryopreservation is one of the most important developments in assisted reproduction supporting the clinical application and improving the efficacy (cumulative pregnancy rate) of assisted reproductive procedures. The objective of our study was to investigate the effect of the different clinical and embryological parameters (year, age and BMI of patients, number and developmental stage of implanted embryos, embryo survival rate, preparation of the patients for frozen embryo transfers, biochemical pregnancies and abortions) on the frozen embryo transfer cycles. The achieved pregnancy rate with frozen-thawed embryos was 28% (156/563). The average age of patients was 32.38+4.88 (22-51 year of age). The probability of pregnancy decreased with the increase in the patients' age (p<0.001), and above 35 years the success of the frozen-thawed embryo transfer cycles dropped dramatically. No difference was found in the BMI of the pregnant and non-pregnant groups, however our data show that in case of low BMI the probability of pregnancy decreases. The type of procedure used for patient preparation and the endometrium for the frozen embryo transfer did not have any effect on the pregnancy rate. Although the data show a tendency that the probability of pregnancy is higher in natural cycles compared with artificial or stimulated cycles. No difference was found in the survival rate after thawing, between the different embryo developmental groups (88%; Day 2, 3 and 5). The probability of pregnancy increased with the age of the implanted embryo, and the highest pregnancy rate was found in the group of Day 5 blastocysts (Day 2: 9/32, 28%; Day 3: 94/347, 27% and Day 5: 25/65, 38; p<0.002). With increasing the number of transferred embryos, the probability of pregnancy establishment increases (p<0.0003). The number of cycles ending with miscarriage was a little bit higher in the group of patients with stimulated cycles (p<0.05); however no difference was found in the number of biochemical pregnancies.
|Translated title of the contribution||Study of various clinical and embryological parameters effecting the frozenthawed IVF-ET and ICSI-ET results|
|Number of pages||8|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2008|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology