Study of triethyl citrate migration from coating polymers to tablet cores

Z. Budavári, Zs Porkoláb, R. Zelkó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Migration of plasticizers from film coating polymers towards the core and to the storage medium could result in serious changes in the mechanical properties and permeability of coatings thus greatly influencing rate and extent of drug release. The purpose of the present study was to follow the migration of water soluble triethyl citrate applied as a plasticizer in Acryl-Eze coating by Gas Chromatography/Mass Spectrometry (GC/ MS). 20%w/w Acryl-Eze dispersions containing triethyl citrate of different concentrations were prepared. Placebo tablets were compressed and coated with the prepared dispersions. The coated tablets were stored under different relative humidity conditions for different time intervals. Considerable migration of triethyl citrate towards the tablet cores was found. The extent of the triethyl citrate migration was influenced by the relative humidity of the storage medium.

Original languageEnglish
Pages (from-to)893-894
Number of pages2
JournalPharmazie
Volume59
Issue number11
Publication statusPublished - Nov 2004

Fingerprint

Tablets
Polymers
Plasticizers
Coatings
Humidity
Dispersions
Atmospheric humidity
Mechanical permeability
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Permeability
Placebos
Mechanical properties
ethyl citrate
Water
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Study of triethyl citrate migration from coating polymers to tablet cores. / Budavári, Z.; Porkoláb, Zs; Zelkó, R.

In: Pharmazie, Vol. 59, No. 11, 11.2004, p. 893-894.

Research output: Contribution to journalArticle

Budavári, Z, Porkoláb, Z & Zelkó, R 2004, 'Study of triethyl citrate migration from coating polymers to tablet cores', Pharmazie, vol. 59, no. 11, pp. 893-894.
Budavári, Z. ; Porkoláb, Zs ; Zelkó, R. / Study of triethyl citrate migration from coating polymers to tablet cores. In: Pharmazie. 2004 ; Vol. 59, No. 11. pp. 893-894.
@article{79b5aa50876247fa9db040a5acede8c3,
title = "Study of triethyl citrate migration from coating polymers to tablet cores",
abstract = "Migration of plasticizers from film coating polymers towards the core and to the storage medium could result in serious changes in the mechanical properties and permeability of coatings thus greatly influencing rate and extent of drug release. The purpose of the present study was to follow the migration of water soluble triethyl citrate applied as a plasticizer in Acryl-Eze coating by Gas Chromatography/Mass Spectrometry (GC/ MS). 20{\%}w/w Acryl-Eze dispersions containing triethyl citrate of different concentrations were prepared. Placebo tablets were compressed and coated with the prepared dispersions. The coated tablets were stored under different relative humidity conditions for different time intervals. Considerable migration of triethyl citrate towards the tablet cores was found. The extent of the triethyl citrate migration was influenced by the relative humidity of the storage medium.",
author = "Z. Budav{\'a}ri and Zs Porkol{\'a}b and R. Zelk{\'o}",
year = "2004",
month = "11",
language = "English",
volume = "59",
pages = "893--894",
journal = "Die Pharmazie",
issn = "0031-7144",
publisher = "Govi-Verlag Pharmazeutischer Verlag GmbH",
number = "11",

}

TY - JOUR

T1 - Study of triethyl citrate migration from coating polymers to tablet cores

AU - Budavári, Z.

AU - Porkoláb, Zs

AU - Zelkó, R.

PY - 2004/11

Y1 - 2004/11

N2 - Migration of plasticizers from film coating polymers towards the core and to the storage medium could result in serious changes in the mechanical properties and permeability of coatings thus greatly influencing rate and extent of drug release. The purpose of the present study was to follow the migration of water soluble triethyl citrate applied as a plasticizer in Acryl-Eze coating by Gas Chromatography/Mass Spectrometry (GC/ MS). 20%w/w Acryl-Eze dispersions containing triethyl citrate of different concentrations were prepared. Placebo tablets were compressed and coated with the prepared dispersions. The coated tablets were stored under different relative humidity conditions for different time intervals. Considerable migration of triethyl citrate towards the tablet cores was found. The extent of the triethyl citrate migration was influenced by the relative humidity of the storage medium.

AB - Migration of plasticizers from film coating polymers towards the core and to the storage medium could result in serious changes in the mechanical properties and permeability of coatings thus greatly influencing rate and extent of drug release. The purpose of the present study was to follow the migration of water soluble triethyl citrate applied as a plasticizer in Acryl-Eze coating by Gas Chromatography/Mass Spectrometry (GC/ MS). 20%w/w Acryl-Eze dispersions containing triethyl citrate of different concentrations were prepared. Placebo tablets were compressed and coated with the prepared dispersions. The coated tablets were stored under different relative humidity conditions for different time intervals. Considerable migration of triethyl citrate towards the tablet cores was found. The extent of the triethyl citrate migration was influenced by the relative humidity of the storage medium.

UR - http://www.scopus.com/inward/record.url?scp=8744228142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8744228142&partnerID=8YFLogxK

M3 - Article

C2 - 15587596

AN - SCOPUS:8744228142

VL - 59

SP - 893

EP - 894

JO - Die Pharmazie

JF - Die Pharmazie

SN - 0031-7144

IS - 11

ER -