Study of trace elements in bioarena system and in in vivo conditions

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1 Citation (Scopus)


The adsorbent layer system is especially suitable for the biological evaluation of different compounds and trace elements as well. Present experiments showed that HCHO molecules participate in the antibiotic activity of Cu (II) ion, an "old antibiotic." The elimination of HCHO from the chromatographic spots (e.g., by reduction or capturing) resulted in a characteristic decrease of the antibiotic effect of trace elements. The trace elements are HCHO carriers and generate a double effect (first step: deprivation of HCHO as the biological effect; second step: release of HCHO with big killing activity). These features offer good opportunities for influencing fundamental biochemical pathways. It has been established that the trace elements (mainly transition metal ions as, e.g., Ni(II) ion) always generate quadruple, bioequivalent, and specific immune-stimulating activity in plants with a non-linear dose-response. HCHO and its reaction products (mainly O3) are responsible also for this latter activity.

Original languageEnglish
Pages (from-to)2857-2871
Number of pages15
JournalJournal of Liquid Chromatography and Related Technologies
Issue number20
Publication statusPublished - Dec 14 2014


  • BioArena
  • antibiotic effect
  • formaldehyde (HCHO)
  • immunization
  • overpressured layer chromatography (OPLC)
  • ozone
  • quadruple bioequivalent immune system
  • trace elements

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Pharmaceutical Science
  • Clinical Biochemistry

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