Study of the theophylline content of single coated particles by gas chromatography/mass spectrometry

Z. Budavári, R. Zelkó, S. Marton, I. Rácz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of the present study was to determine by gas chromatography/mass spectrometry (GC/MS) the content uniformity of single theophylline microcapsules of different particle size ranges. Microencapsulation was carried out in a laboratory fluidized bed system using Eudragit L30D aqueous dispersion. Scanning electron microscopy was applied for the characterization of the surface morphology of the prepared theophylline microcapsules of two different particle size ranges. The theophylline content of single particles was determined by GC/MS analysis. It was found that the particle size of microcapsules greatly influenced their theophylline content. The GC/MS analysis was successfully applied to indicate the changes in the content uniformity and thus the interparticular coating distribution of single theophylline microcapsules in the presence of several excipients.

Original languageEnglish
Pages (from-to)991-995
Number of pages5
JournalDrug Development and Industrial Pharmacy
Volume27
Issue number9
DOIs
Publication statusPublished - 2001

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Theophylline
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Capsules
Particle Size
Particle size
Microencapsulation
Drug Compounding
Excipients
Electron Scanning Microscopy
Fluidized beds
Surface morphology
Coatings
Scanning electron microscopy

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

Study of the theophylline content of single coated particles by gas chromatography/mass spectrometry. / Budavári, Z.; Zelkó, R.; Marton, S.; Rácz, I.

In: Drug Development and Industrial Pharmacy, Vol. 27, No. 9, 2001, p. 991-995.

Research output: Contribution to journalArticle

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