Study of the preparation of a multiparticulate drug delivery system with a layering technique

Krisztina Nikowitz, Péter Kása, Klára Pintye-Hódi, Géza Regdon

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16 Citations (Scopus)

Abstract

The properties of a fully formulated enteric coating system were examined on a model multiparticulate formulation. Samples containing the model drug diltiazem hydrochloride were made in a fluid bed chamber with different amounts of Acryl-EZE, a ready-to-use coating dispersion. The effects of the film thickness on the dissolution profile were determined. While all samples yielded satisfactory release results in simulated intestinal fluid, the results in simulated gastric acid were worse than expected. The scanning electron microscopic images suggested that coating problems were not responsible for this behaviour.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalPowder Technology
Volume205
Issue number1-3
DOIs
Publication statusPublished - Jan 10 2011

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Keywords

  • Acryl-EZE
  • Dissolution
  • Enteric coating
  • Multiparticulate

ASJC Scopus subject areas

  • Chemical Engineering(all)

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