Study of the parameters influencing the co-grinding process for the production of meloxicam nanoparticles

Levente Kürti, Ákos Kukovecz, Gábor Kozma, Rita Ambrus, Mária A. Deli, Piroska Szabó-Révész

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Co-grinding is a procedure for the preparation of nanoparticles in which the drug is ground together with one or more excipients. The grinding of meloxicam, a crystalline solid, together with amorphous polyvinylpyrrolidone (PVP) or semi-crystalline polyethylene glycol (PEG) as excipients, is expected to lead to a drastic reduction in particle size. We optimized meloxicam grinding using a three level full factorial response surface design. In the case of PVP the optimum co-grinding parameter set in our study proved to be a meloxicam to PVP-C30 ratio of 1:1, and a rotation frequency of 400rpm. The best size reduction was achieved at a meloxicam to PEG 6000 ratio=1:2 at a rotation frequency of 400rpm: nanoparticles averaging dSEM=174nm in diameter and with a very narrow size distribution (standard deviation 35% of mean) were obtained. X-ray powder diffraction analysis indicated that the optimized products contained amorphous meloxicam nanoparticles in the PVP-C30 composition, although meloxicam nanocrystals could also be detected in the samples which contained PEG 6000. The dissolution properties were significantly increased under nasal conditions (pH 5.1, temperature 30°C), especially in the case of the amorphous product. Such dry powder systems can offer novel opportunities in systemic nasal drug delivery.

Original languageEnglish
Pages (from-to)210-217
Number of pages8
JournalPowder Technology
Volume212
Issue number1
DOIs
Publication statusPublished - Sep 15 2011

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Keywords

  • Co-grinding
  • Factorial experimental design
  • Meloxicam
  • Nanoparticle
  • Nasal powder system
  • Scanning electron microscopy

ASJC Scopus subject areas

  • Chemical Engineering(all)

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