Study of the melanin in paraffin embedded specimens of ocular melanoma by electron spin resonance (ESP)

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Abstract

The Electron Spin Resonance (ESP) spectrum of ocular melanomas embedded in paraffin was studied. In the g~2.003 range of the spectrum a mark of a free radical was detected. The correlation between the amplitude of the latter and the number of melanin granules in sections was studied. Considering the positive correlation revealed, the authors believe that ESR spectroscopy is a suitable tool for detecting melanin in paraffin embedded specimens. As an effect of oxidation or reduction melanin turns pale; however this phenomenon is not in close connection with the decrease of the amplitude of the free-radical-mark. Very seldomly different types of spectrum (peroxide, cupri-ion) may appear, so it is reasonable to study large numbers of specimens.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalMorphologiai es igazsagugyi orvosi szemle
Volume20
Issue number3
Publication statusPublished - 1980

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Melanins
Electron Spin Resonance Spectroscopy
Paraffin
Melanoma
Free Radicals
Peroxides
Spectrum Analysis
Ions

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Study of the melanin in paraffin embedded specimens of ocular melanoma by electron spin resonance (ESP)",
abstract = "The Electron Spin Resonance (ESP) spectrum of ocular melanomas embedded in paraffin was studied. In the g~2.003 range of the spectrum a mark of a free radical was detected. The correlation between the amplitude of the latter and the number of melanin granules in sections was studied. Considering the positive correlation revealed, the authors believe that ESR spectroscopy is a suitable tool for detecting melanin in paraffin embedded specimens. As an effect of oxidation or reduction melanin turns pale; however this phenomenon is not in close connection with the decrease of the amplitude of the free-radical-mark. Very seldomly different types of spectrum (peroxide, cupri-ion) may appear, so it is reasonable to study large numbers of specimens.",
author = "G. Elek and K. Lapis and A. Rockenbauer",
year = "1980",
language = "English",
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pages = "219--224",
journal = "Morphologiai es igazsagugyi orvosi szemle",
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T1 - Study of the melanin in paraffin embedded specimens of ocular melanoma by electron spin resonance (ESP)

AU - Elek, G.

AU - Lapis, K.

AU - Rockenbauer, A.

PY - 1980

Y1 - 1980

N2 - The Electron Spin Resonance (ESP) spectrum of ocular melanomas embedded in paraffin was studied. In the g~2.003 range of the spectrum a mark of a free radical was detected. The correlation between the amplitude of the latter and the number of melanin granules in sections was studied. Considering the positive correlation revealed, the authors believe that ESR spectroscopy is a suitable tool for detecting melanin in paraffin embedded specimens. As an effect of oxidation or reduction melanin turns pale; however this phenomenon is not in close connection with the decrease of the amplitude of the free-radical-mark. Very seldomly different types of spectrum (peroxide, cupri-ion) may appear, so it is reasonable to study large numbers of specimens.

AB - The Electron Spin Resonance (ESP) spectrum of ocular melanomas embedded in paraffin was studied. In the g~2.003 range of the spectrum a mark of a free radical was detected. The correlation between the amplitude of the latter and the number of melanin granules in sections was studied. Considering the positive correlation revealed, the authors believe that ESR spectroscopy is a suitable tool for detecting melanin in paraffin embedded specimens. As an effect of oxidation or reduction melanin turns pale; however this phenomenon is not in close connection with the decrease of the amplitude of the free-radical-mark. Very seldomly different types of spectrum (peroxide, cupri-ion) may appear, so it is reasonable to study large numbers of specimens.

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