Study of the mechanism of the optical resolution of N-methylamphetamine via diastereoisomeric salt formation by the Pope-Peachey method

Dávid Kozma, Zoltán Madarász, Mária Ács, Elemér Foggasy

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Abstract

During the optical resolution of racemic N-methylamphetamine by half an equivalent of R,R-tartaric acid in the presence of half an equivalent of hydrochloric acid the tartrate salt of the R-base precipitates with a low optical purity. The optical purity of the precipitated salt is increased by enantiomer exchange between the solid and solvent phase.

Original languageEnglish
Pages (from-to)193-194
Number of pages2
JournalTetrahedron: Asymmetry
Volume5
Issue number2
DOIs
Publication statusPublished - 1994

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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