Study of the mechanism of optical resolutions via diastereoisomeric salt formation: V. Thermoanalytical investigation of the optical resolution of the N-methylamphetamine by tartaric acid

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Abstract

The products obtained in the optical resolution of the N-methylamphetamine by the Pope-Peachy method, using half equivalent R, R-tartaric acid and half equivalent hydrochloric acid in absolute ethanol were investigated by thermoanalytical methods. The DSC measurements of the precipitated salts provide sufficient information for following the progress of the resolution. In this way, the results of the resolution can be estimated with the precision of about 5% optical purity.

Original languageEnglish
Pages (from-to)727-733
Number of pages7
JournalJournal of thermal analysis
Volume47
Issue number3
DOIs
Publication statusPublished - Sep 1996

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Keywords

  • Optical resolution
  • Phase diagrams

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Engineering(all)

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