Lipidmembranok neutralis polimerek kolcsonhatasanak differencial 'scanning' kalorimetrias (DSC) vizsgalata

Translated title of the contribution: Study of the interaction of lipidmembrane and neutral polymers by DSC

Grohmann Ferenc Levente, Szogyi Mária, Csempesz Ferenc

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Polymer-free and polymer-bearing liposomes from dimyristoylphosphatidylcholine (DMPC), dimyristoylphosphatidylglycerol (DMPG) and cholesterol (Ch) 10:1:1 (w/w/w) were pre- pared. Polymer-bearing liposomes were formed by incorporating an uncharged polymer [poly(vinyl alcohol) (PVA), poly(vinyl alcohol-co-vinylacetal) (PVA-Al), poly(vinyl alcohol-co-vinyl propional) (PVA-Prol) poly(vinyl alcohol-co-vinyl butiral) (PVA-Bul) copolymer, polyvinyl pyrrolidone (PVP) or polyethylene glycol (PEG) respectively]. The effect of some polymers on the phase transition parameter of phospholipids (DMPC and DMPG) has been studied by differential scanning calorimetry (DSC). DSC has become a standard technique for studying the thermally induced transition of phospholipid molecules from an ordered crystalline-like state at low temperature (gel phase) to a liquid crystalline-like state at higher temperature. The interaction between phospholipids and polymers was characterized by the alteration of the phase transition parameters (T(p), T(m), AT 1/4 ΔH(p), ΔI-I(m)) measured by DSC. It was observed that some phase transition parameters were affected by all polymers but in different extent. PVA-Prol copolymer exibited a prominent effect in increasing the membrane coop- erativity. The influence of PVA-Bul was unique; it decreased the cooperativity of phospholipid molecules. It was also shown that the lipid membranepolymer interac- tion considerably depends on both the chemical structure and the molecular mass of the polymers.

Translated title of the contributionStudy of the interaction of lipidmembrane and neutral polymers by DSC
Original languageBulgarian
Pages (from-to)267-272
Number of pages6
JournalActa pharmaceutica Hungarica
Volume67
Issue number6
Publication statusPublished - Nov 1 1997

ASJC Scopus subject areas

  • Pharmaceutical Science

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