Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat.

K. Nosztray, J. Szabó, I. E. Takács, J. Szegi

Research output: Contribution to journalArticle

Abstract

Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy. The purpose of the present study was to determine the effect of prophylactic + simultaneous digitoxin treatments on the development of T4-induced cardiac hypertrophy. Digitoxin (1 mg/kg body weight) was given per os, once daily for 6 days prior to T4 administration and continued simultaneously with T4 treatment. To determine myocardial enlargement, wet heart weight, myocardial nucleic acid and protein were measured. Digitoxin treatment induced a slight increase in wet ventricle weight and a significant elevation of myocardial RNA content (mg/ventricles) and concentration (mg/g). At the same time, the degree of T4-induced cardiac hypertrophy in digitoxin-treated and untreated animals was nearly the same. On the basis of these results it can be stated that--unlike the cardiac hypertrophy induced by pressure overload or hypoxia,--the T4-induced cardiac hypertrophy is not altered by digitoxin administration.

Original languageEnglish
Pages (from-to)209-218
Number of pages10
JournalActa Biologica Hungarica
Volume37
Issue number3-4
Publication statusPublished - 1986

Fingerprint

digitoxin
Digitoxin
L-thyroxine
Cardiomegaly
thyroxine
Thyroxine
hypertrophy
Rats
rats
Growth
nucleic acid
hypoxia
RNA
Weights and Measures
protein
animal
Nucleic Acids
Animals
nucleic acids
heart

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat. / Nosztray, K.; Szabó, J.; Takács, I. E.; Szegi, J.

In: Acta Biologica Hungarica, Vol. 37, No. 3-4, 1986, p. 209-218.

Research output: Contribution to journalArticle

@article{6164342c7a9844b7900e33f285a2c286,
title = "Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat.",
abstract = "Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy. The purpose of the present study was to determine the effect of prophylactic + simultaneous digitoxin treatments on the development of T4-induced cardiac hypertrophy. Digitoxin (1 mg/kg body weight) was given per os, once daily for 6 days prior to T4 administration and continued simultaneously with T4 treatment. To determine myocardial enlargement, wet heart weight, myocardial nucleic acid and protein were measured. Digitoxin treatment induced a slight increase in wet ventricle weight and a significant elevation of myocardial RNA content (mg/ventricles) and concentration (mg/g). At the same time, the degree of T4-induced cardiac hypertrophy in digitoxin-treated and untreated animals was nearly the same. On the basis of these results it can be stated that--unlike the cardiac hypertrophy induced by pressure overload or hypoxia,--the T4-induced cardiac hypertrophy is not altered by digitoxin administration.",
author = "K. Nosztray and J. Szab{\'o} and Tak{\'a}cs, {I. E.} and J. Szegi",
year = "1986",
language = "English",
volume = "37",
pages = "209--218",
journal = "Acta Biologica Hungarica",
issn = "0236-5383",
publisher = "Akademiai Kiado",
number = "3-4",

}

TY - JOUR

T1 - Study of the factors influencing cardiac growth. III. Digitoxin treatment and thyroxine-induced cardiac hypertrophy in the rat.

AU - Nosztray, K.

AU - Szabó, J.

AU - Takács, I. E.

AU - Szegi, J.

PY - 1986

Y1 - 1986

N2 - Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy. The purpose of the present study was to determine the effect of prophylactic + simultaneous digitoxin treatments on the development of T4-induced cardiac hypertrophy. Digitoxin (1 mg/kg body weight) was given per os, once daily for 6 days prior to T4 administration and continued simultaneously with T4 treatment. To determine myocardial enlargement, wet heart weight, myocardial nucleic acid and protein were measured. Digitoxin treatment induced a slight increase in wet ventricle weight and a significant elevation of myocardial RNA content (mg/ventricles) and concentration (mg/g). At the same time, the degree of T4-induced cardiac hypertrophy in digitoxin-treated and untreated animals was nearly the same. On the basis of these results it can be stated that--unlike the cardiac hypertrophy induced by pressure overload or hypoxia,--the T4-induced cardiac hypertrophy is not altered by digitoxin administration.

AB - Thyroxine (T4) administered to rats in a dose of 1 mg/kg for 12 days induces cardiac hypertrophy. The purpose of the present study was to determine the effect of prophylactic + simultaneous digitoxin treatments on the development of T4-induced cardiac hypertrophy. Digitoxin (1 mg/kg body weight) was given per os, once daily for 6 days prior to T4 administration and continued simultaneously with T4 treatment. To determine myocardial enlargement, wet heart weight, myocardial nucleic acid and protein were measured. Digitoxin treatment induced a slight increase in wet ventricle weight and a significant elevation of myocardial RNA content (mg/ventricles) and concentration (mg/g). At the same time, the degree of T4-induced cardiac hypertrophy in digitoxin-treated and untreated animals was nearly the same. On the basis of these results it can be stated that--unlike the cardiac hypertrophy induced by pressure overload or hypoxia,--the T4-induced cardiac hypertrophy is not altered by digitoxin administration.

UR - http://www.scopus.com/inward/record.url?scp=0022830253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022830253&partnerID=8YFLogxK

M3 - Article

C2 - 2450432

AN - SCOPUS:0022830253

VL - 37

SP - 209

EP - 218

JO - Acta Biologica Hungarica

JF - Acta Biologica Hungarica

SN - 0236-5383

IS - 3-4

ER -