Study of the effects of paraquat on the peroxide metabolism enzymes in guinea-pig

Katalin Barabás, L. Szabó, Sz I. Varga, G. Berencsi, A. Bartkowiak, B. Matkovics

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. 1. Guinea-pigs, which exhibit a similar metabolism to that of man insofar as they are incapable of synthesizing ascorbic acid, were poisoned with Gramoxon® containing the LD50 or LD100 of paraquat. 2. 2. A study was made of how the paraquat poisoning affected previously investigated tissue parameters, the superoxide dismutase, catalase and glutathione peroxidase activities and the lipid peroxidation. 3. 3. In accordance with earlier results, the paraquat influences these parameters in different ways in all the tissues examined, depending on its concentration. 4. 4. These parameters comprise primarily affected systems as regards paraquat toxicity.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalGeneral Pharmacology
Volume13
Issue number2
DOIs
Publication statusPublished - 1982

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Paraquat
Peroxides
Guinea Pigs
Enzymes
Lethal Dose 50
Glutathione Peroxidase
Catalase
Poisoning
Lipid Peroxidation
Ascorbic Acid
Superoxide Dismutase

ASJC Scopus subject areas

  • Pharmacology

Cite this

Study of the effects of paraquat on the peroxide metabolism enzymes in guinea-pig. / Barabás, Katalin; Szabó, L.; Varga, Sz I.; Berencsi, G.; Bartkowiak, A.; Matkovics, B.

In: General Pharmacology, Vol. 13, No. 2, 1982, p. 133-137.

Research output: Contribution to journalArticle

Barabás, Katalin ; Szabó, L. ; Varga, Sz I. ; Berencsi, G. ; Bartkowiak, A. ; Matkovics, B. / Study of the effects of paraquat on the peroxide metabolism enzymes in guinea-pig. In: General Pharmacology. 1982 ; Vol. 13, No. 2. pp. 133-137.
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