Study of the Distribution of Magnesium Stearate with an Energy Dispersive X-ray Fluorescence Analyser

Annamária Szalay, Klára Pintye-Hódi, Katalin Joó, István Eros

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The formulation of tablets requires various auxiliaries. One group of these ingredients is the lubricants, which prevent ticking to the die and punches and minimize their wear. In the pharmaceutical industry, one of the well-known and probably the most widely used lubricants is magnesium stearate. Its use is considered essential, as magnesium stearate forms a film of low shear strength between the die wall and the compact and reduces friction; it has few properties which negatively influence the overall. The aim of this work was to study whether particle size of sorbitol has any effect on the distribution of magnesium stearate in a tablet during compression. The distribution of magnesium stearate on the surface of the particles was measured with an energy dispersive X-ray fluorescence analyser.

Original languageEnglish
Pages (from-to)221-223
Number of pages3
JournalPharmazeutische Industrie
Volume66
Issue number2
Publication statusPublished - 2004

Keywords

  • Magnesium stearate
  • Sorbitol, particle fractions, tabletting
  • Tabletting lubricants, magnesium distribution
  • X-ray flourescence analysis

ASJC Scopus subject areas

  • Pharmaceutical Science

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