Study of the diastereoisomers formed between (N-alkyl)-pipecolic acid-anilides and 2R,3R-tartaric acid or O,O′-dibenzoyl-2R,3R-tartaric acid. Do the tartaric acids form molecular-complexes, instead of salts during optical resolutions?

Katalin Nemák, Mária Ács, Zsuzsa M. Jászay, Dávid Kozma, Elemér Fogassy

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

It was found that during the optical resolution of (N-alkyl)-pipecolic acid-anilides by 2R,3R-tartaric acid and O,O′-dibenzoyl-2R,3R-tartaric acid that the precipitated diastereoisomer was not the salt but a diastereoisomeric complex in 8 cases from 13. The results indicate that tartaric acids may be used as general resolving agents for optical resolution of racemates even having no basic group.

Original languageEnglish
Pages (from-to)1637-1642
Number of pages6
JournalTetrahedron
Volume52
Issue number5
DOIs
Publication statusPublished - Jan 29 1996

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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