Study of the cellular mechanism of the blockade of Kupffer cell phagocytosis induced by gadolinium chloride

E. Husztik, G. Larzar, A. Parducz

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Abstract

Studying the distribution of heterologous erythrocytes labelled by Cr 51 in rats, it was established that reticuloendothelial blockade induced by gadolinium chloride can be explained by the decreased phagocytic activity of Kupffer cells. Light- and electronmicroscopic studies have shown that gadolinium chloride inhibited phagocytosis of India ink not only by normal, non activated Kupffer cells but also by those activated by a reticuloendithelial stimulator, zymosan. These experiments seem to indicate that in blockade of Kupffer cell phagocytosis induced by gadolinium chloride both phases of this process, the surface sticking and engulfing, are damaged.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalMorphologiai es Igazsagugyi Orvosi Szemle
Volume21
Issue number1
Publication statusPublished - Jan 1 1981

ASJC Scopus subject areas

  • Medicine(all)

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