Study of the antitumoral activity of S-carbamoyl-L-cysteine derivatives in animal experiments

L. Nemeth, S. Somfai-Relle, B. Kellner, J. Sugár, R. Bognár, J. Farkas, J. Bálint, I. Pályi, K. Tóth, Z. Szentirmay, Z. Somosy, E. Pokorny

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Abstract

The antitumoral activity of three amino acid derivatives, S-carbamoyl-L-cysteine, S-ethyl-carbamoyl-L-cysteine, and S-chloroethyl-carbamoyl-L-cysteine, was studied. The ethyl and chloroethyl derivatives had a pronounced curative effect on certain animal tumors. It is interesting in the case of S-carbamoyl-L-cysteine that N-ethylization of the substance resulted in increased chemotherapeutic effectivity with no simultaneous change of the toxicity. According to various studies this effect is different in many respects from that of the known cytostatics and a possibility of a specific selective or surface activity is raised.

Original languageEnglish
Pages (from-to)1119-1123
Number of pages5
JournalArzneimittel-Forschung
Volume28
Issue number7
Publication statusPublished - 1978

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Cysteine
Animals
Derivatives
Experiments
Cytostatic Agents
Toxicity
Tumors
Amino Acids
Neoplasms

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Nemeth, L., Somfai-Relle, S., Kellner, B., Sugár, J., Bognár, R., Farkas, J., ... Pokorny, E. (1978). Study of the antitumoral activity of S-carbamoyl-L-cysteine derivatives in animal experiments. Arzneimittel-Forschung, 28(7), 1119-1123.

Study of the antitumoral activity of S-carbamoyl-L-cysteine derivatives in animal experiments. / Nemeth, L.; Somfai-Relle, S.; Kellner, B.; Sugár, J.; Bognár, R.; Farkas, J.; Bálint, J.; Pályi, I.; Tóth, K.; Szentirmay, Z.; Somosy, Z.; Pokorny, E.

In: Arzneimittel-Forschung, Vol. 28, No. 7, 1978, p. 1119-1123.

Research output: Contribution to journalArticle

Nemeth, L, Somfai-Relle, S, Kellner, B, Sugár, J, Bognár, R, Farkas, J, Bálint, J, Pályi, I, Tóth, K, Szentirmay, Z, Somosy, Z & Pokorny, E 1978, 'Study of the antitumoral activity of S-carbamoyl-L-cysteine derivatives in animal experiments', Arzneimittel-Forschung, vol. 28, no. 7, pp. 1119-1123.
Nemeth L, Somfai-Relle S, Kellner B, Sugár J, Bognár R, Farkas J et al. Study of the antitumoral activity of S-carbamoyl-L-cysteine derivatives in animal experiments. Arzneimittel-Forschung. 1978;28(7):1119-1123.
Nemeth, L. ; Somfai-Relle, S. ; Kellner, B. ; Sugár, J. ; Bognár, R. ; Farkas, J. ; Bálint, J. ; Pályi, I. ; Tóth, K. ; Szentirmay, Z. ; Somosy, Z. ; Pokorny, E. / Study of the antitumoral activity of S-carbamoyl-L-cysteine derivatives in animal experiments. In: Arzneimittel-Forschung. 1978 ; Vol. 28, No. 7. pp. 1119-1123.
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