Study of the antidiuretic effect of clofibrate in rat

L. Czako, E. Nagy, I. Szilagyi, F. A. Laszlo

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Abstract

The effect of clofibrate on the water metabolism was studied in rats with pituitary stalk lesion. It was found that this drug made the oliguria interphase much more marked and more prolonged. In rats anaesthetized with alcohol, clofibrate pre-treatment led to an enhancement of the effect of ADH. The experiments permit the conclusion that the presence of endogenous ADH is necessary for clofibrate antidiuresis. Its effect is presumably exerted via the mobilization of the ADH, but it cannot be excluded that it also enhances the peripheral effect of ADH.

Original languageEnglish
Pages (from-to)235-238
Number of pages4
JournalEndokrinologie
Volume68
Issue number2
Publication statusPublished - Dec 1 1976

ASJC Scopus subject areas

  • Endocrinology

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  • Cite this

    Czako, L., Nagy, E., Szilagyi, I., & Laszlo, F. A. (1976). Study of the antidiuretic effect of clofibrate in rat. Endokrinologie, 68(2), 235-238.