Study of the analgesic effects of galanthamine, a cholinesterase inhibitor

D. A. Cozanitis, T. Friedmann, S. Fürst

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effects of galanthamine, an alkaloidal anticholinesterase agent whose chemical structure bears similarity to codeine, was studied in various animal and isolated organ tests. Antinociceptive activity of galanthamine given subcutaneously was detected and compared to physostigmine and morphine in the rat hot plate test. Naloxone partially blocked the effect of galanthamine but not that of physostigmine. Both cholinesterase inhibitors provided analgesia in the mouse acetic acid writhing test. They potentiated the effect of morphine in the rat hot plate test but inhibited the barbiturate anaesthesia potentiation of morphine in the rat. While galanthamine provided analgesia in the intact animal, it failed to produce opiate-like activity in such isolated organs as longitudinal muscle strip of the guinea-pig ileum, mouse vas deferens, and cat nictitating membrane.

Original languageEnglish
Pages (from-to)229-238
Number of pages10
JournalArchives Internationales de Pharmacodynamie et de Therapie
Volume266
Issue number2
Publication statusPublished - 1983

Fingerprint

Galantamine
Cholinesterase Inhibitors
Analgesics
Morphine
Physostigmine
Analgesia
Opiate Alkaloids
Nictitating Membrane
Animal Structures
Codeine
Vas Deferens
Naloxone
Ileum
Acetic Acid
Guinea Pigs
Cats
Anesthesia
Muscles

ASJC Scopus subject areas

  • Pharmacology

Cite this

Study of the analgesic effects of galanthamine, a cholinesterase inhibitor. / Cozanitis, D. A.; Friedmann, T.; Fürst, S.

In: Archives Internationales de Pharmacodynamie et de Therapie, Vol. 266, No. 2, 1983, p. 229-238.

Research output: Contribution to journalArticle

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