Az Epstein-Barr vírus patogenetikai szerepének tanulmányozása magyarországi B-sejtes non-Hodgkin lymphomás betegekben.

Translated title of the contribution: Study of pathogenetic role of Epstein-Barr virus in Hungarian patients with B-cell non-Hodgkin lymphomas

Péter Germán, Zoltán Beck, Imre Semsei, Sándor Kiss, Balázs Görög, Erzsébet Balogh, F. Tóth, Z. Nemes, László Pajor, E. Oláh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

INTRODUCTION: The Epstein-Barr virus is a member of herpesvirus family. It plays an important role in the etiopathogenesis of Burkitt lymphoma, other B-cell non-Hodgkin lymphomas, nasopharyngeal carcinoma, X chromosome-linked lymphoproliferative disease, Hodgkin lymphomas and a part of T-cell lymphomas. It has been suggested that association of Epstein-Barr virus with lymphomas and its pathological significance in disease varies in different geographical areas. The aim of our study was to reveal the role of Epstein-Barr virus in B-cell non-Hodgkin lymphomas diagnosed in Hungary. The authors asked: A) What is the frequency of the presence of virus genome in the biopsy specimen from B-cell non-Hodgkin patients? B) Which types of virus latency can be observed? PATIENTS AND METHODS: Genomic DNA and EBER-specific RNA of Epstein-Barr virus in paraffin-embedded specimens were detected by polymerase chain reaction and in situ hybridisation, respectively. RESULTS: Out of 36 B-cell non-Hodgkin lymphoma cases, 16 (45%) were found to be positive for Epstein-Barr virus by the above methods. Expression of latency genes, nuclear antigene-2 and latent membrane protein-1 was studied by immunohistochemical technique. The 16 virus-positive non-Hodgkin lymphoma cases showed Epstein-Barr virus latency types II. (37%) or III. (63%). CONCLUSIONS: The authors data suggest that Epstein-Barr virus may be associated with the development of B-cell non-Hodgkin lymphomas in Hungarian patients.

Original languageHungarian
Pages (from-to)2619-2624
Number of pages6
JournalOrvosi Hetilap
Volume143
Issue number47
Publication statusPublished - Nov 24 2002

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B-Cell Lymphoma
Human Herpesvirus 4
Non-Hodgkin's Lymphoma
Virus Latency
Viruses
Cercopithecine Herpesvirus 1
Burkitt Lymphoma
Lymphoproliferative Disorders
Hungary
T-Cell Lymphoma
Herpesviridae
X Chromosome
Hodgkin Disease
Paraffin
In Situ Hybridization
Lymphoma
Membrane Proteins
B-Lymphocytes
Genome
RNA

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az Epstein-Barr vírus patogenetikai szerepének tanulmányozása magyarországi B-sejtes non-Hodgkin lymphomás betegekben. / Germán, Péter; Beck, Zoltán; Semsei, Imre; Kiss, Sándor; Görög, Balázs; Balogh, Erzsébet; Tóth, F.; Nemes, Z.; Pajor, László; Oláh, E.

In: Orvosi Hetilap, Vol. 143, No. 47, 24.11.2002, p. 2619-2624.

Research output: Contribution to journalArticle

Germán, P, Beck, Z, Semsei, I, Kiss, S, Görög, B, Balogh, E, Tóth, F, Nemes, Z, Pajor, L & Oláh, E 2002, 'Az Epstein-Barr vírus patogenetikai szerepének tanulmányozása magyarországi B-sejtes non-Hodgkin lymphomás betegekben.', Orvosi Hetilap, vol. 143, no. 47, pp. 2619-2624.
Germán P, Beck Z, Semsei I, Kiss S, Görög B, Balogh E et al. Az Epstein-Barr vírus patogenetikai szerepének tanulmányozása magyarországi B-sejtes non-Hodgkin lymphomás betegekben. Orvosi Hetilap. 2002 Nov 24;143(47):2619-2624.
Germán, Péter ; Beck, Zoltán ; Semsei, Imre ; Kiss, Sándor ; Görög, Balázs ; Balogh, Erzsébet ; Tóth, F. ; Nemes, Z. ; Pajor, László ; Oláh, E. / Az Epstein-Barr vírus patogenetikai szerepének tanulmányozása magyarországi B-sejtes non-Hodgkin lymphomás betegekben. In: Orvosi Hetilap. 2002 ; Vol. 143, No. 47. pp. 2619-2624.
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abstract = "INTRODUCTION: The Epstein-Barr virus is a member of herpesvirus family. It plays an important role in the etiopathogenesis of Burkitt lymphoma, other B-cell non-Hodgkin lymphomas, nasopharyngeal carcinoma, X chromosome-linked lymphoproliferative disease, Hodgkin lymphomas and a part of T-cell lymphomas. It has been suggested that association of Epstein-Barr virus with lymphomas and its pathological significance in disease varies in different geographical areas. The aim of our study was to reveal the role of Epstein-Barr virus in B-cell non-Hodgkin lymphomas diagnosed in Hungary. The authors asked: A) What is the frequency of the presence of virus genome in the biopsy specimen from B-cell non-Hodgkin patients? B) Which types of virus latency can be observed? PATIENTS AND METHODS: Genomic DNA and EBER-specific RNA of Epstein-Barr virus in paraffin-embedded specimens were detected by polymerase chain reaction and in situ hybridisation, respectively. RESULTS: Out of 36 B-cell non-Hodgkin lymphoma cases, 16 (45{\%}) were found to be positive for Epstein-Barr virus by the above methods. Expression of latency genes, nuclear antigene-2 and latent membrane protein-1 was studied by immunohistochemical technique. The 16 virus-positive non-Hodgkin lymphoma cases showed Epstein-Barr virus latency types II. (37{\%}) or III. (63{\%}). CONCLUSIONS: The authors data suggest that Epstein-Barr virus may be associated with the development of B-cell non-Hodgkin lymphomas in Hungarian patients.",
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T1 - Az Epstein-Barr vírus patogenetikai szerepének tanulmányozása magyarországi B-sejtes non-Hodgkin lymphomás betegekben.

AU - Germán, Péter

AU - Beck, Zoltán

AU - Semsei, Imre

AU - Kiss, Sándor

AU - Görög, Balázs

AU - Balogh, Erzsébet

AU - Tóth, F.

AU - Nemes, Z.

AU - Pajor, László

AU - Oláh, E.

PY - 2002/11/24

Y1 - 2002/11/24

N2 - INTRODUCTION: The Epstein-Barr virus is a member of herpesvirus family. It plays an important role in the etiopathogenesis of Burkitt lymphoma, other B-cell non-Hodgkin lymphomas, nasopharyngeal carcinoma, X chromosome-linked lymphoproliferative disease, Hodgkin lymphomas and a part of T-cell lymphomas. It has been suggested that association of Epstein-Barr virus with lymphomas and its pathological significance in disease varies in different geographical areas. The aim of our study was to reveal the role of Epstein-Barr virus in B-cell non-Hodgkin lymphomas diagnosed in Hungary. The authors asked: A) What is the frequency of the presence of virus genome in the biopsy specimen from B-cell non-Hodgkin patients? B) Which types of virus latency can be observed? PATIENTS AND METHODS: Genomic DNA and EBER-specific RNA of Epstein-Barr virus in paraffin-embedded specimens were detected by polymerase chain reaction and in situ hybridisation, respectively. RESULTS: Out of 36 B-cell non-Hodgkin lymphoma cases, 16 (45%) were found to be positive for Epstein-Barr virus by the above methods. Expression of latency genes, nuclear antigene-2 and latent membrane protein-1 was studied by immunohistochemical technique. The 16 virus-positive non-Hodgkin lymphoma cases showed Epstein-Barr virus latency types II. (37%) or III. (63%). CONCLUSIONS: The authors data suggest that Epstein-Barr virus may be associated with the development of B-cell non-Hodgkin lymphomas in Hungarian patients.

AB - INTRODUCTION: The Epstein-Barr virus is a member of herpesvirus family. It plays an important role in the etiopathogenesis of Burkitt lymphoma, other B-cell non-Hodgkin lymphomas, nasopharyngeal carcinoma, X chromosome-linked lymphoproliferative disease, Hodgkin lymphomas and a part of T-cell lymphomas. It has been suggested that association of Epstein-Barr virus with lymphomas and its pathological significance in disease varies in different geographical areas. The aim of our study was to reveal the role of Epstein-Barr virus in B-cell non-Hodgkin lymphomas diagnosed in Hungary. The authors asked: A) What is the frequency of the presence of virus genome in the biopsy specimen from B-cell non-Hodgkin patients? B) Which types of virus latency can be observed? PATIENTS AND METHODS: Genomic DNA and EBER-specific RNA of Epstein-Barr virus in paraffin-embedded specimens were detected by polymerase chain reaction and in situ hybridisation, respectively. RESULTS: Out of 36 B-cell non-Hodgkin lymphoma cases, 16 (45%) were found to be positive for Epstein-Barr virus by the above methods. Expression of latency genes, nuclear antigene-2 and latent membrane protein-1 was studied by immunohistochemical technique. The 16 virus-positive non-Hodgkin lymphoma cases showed Epstein-Barr virus latency types II. (37%) or III. (63%). CONCLUSIONS: The authors data suggest that Epstein-Barr virus may be associated with the development of B-cell non-Hodgkin lymphomas in Hungarian patients.

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