Study of lymphocyte subpopulations in patients with systemic lupus erythematosus. In vitro effect of levamisole on T-lymphocyte population

T. Pozsonyi, L. Jakab, J. Fehér

Research output: Contribution to journalArticle

Abstract

Peripheral blood lymphocytes and the 'in vitro' changes of the T-cell count after levamisole treatment were studied in twenty-two patients with systemic lupus erythematosus and in eighteen normal controls using E-rosette assay to quantify T-cells and EAC-assay to quantify B-lymphocytes. T-cell count was significantly lower in the patient group compared with the control group. B-cell numbers did not change significantly. The decrease of the T-cell count was accompanied by an increase of the null-cell number in patient groups. The levamisole treatment 'in vitro' produced an increase in the active-T and total T-lymphocyte counts and led to the decrease of null-cell numbers. These data confirm the available evidence that levamisole 'in vitro' may induce the maturation of immature T-lymphocytes in SLE.

Original languageEnglish
Pages (from-to)553-558
Number of pages6
JournalAllergologia et Immunopathologia
Volume8
Issue number5
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Immunology and Allergy

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