Study of isolated apparent amniogenic limb deficiency in Hungary, 1975- 1984

A. E. Czeizel, M. Vitez, I. Kodaj, W. Lenz

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15 Citations (Scopus)

Abstract

A population-based and validated data set of 206 cases with apparent amniogenic limb deficiency was ascertained in Hungary between 1975 and 1984. Such limb defects frequently (36%) associated with nonlimb abnormalities. In 134 cases with isolated defects typically more limbs are affected, upper and lower limbs, right and left sides, and both sexes are equally affected. Case- control analysis of such isolated cases indicates a lower socioeconomic status of parents, a higher parity, more frequent unwanted pregnancies, preterm birth, and a higher rate of threatened abortion. Familial occurrence was not found in 415 first-degree relatives.

Original languageEnglish
Pages (from-to)372-378
Number of pages7
JournalAmerican journal of medical genetics
Volume46
Issue number4
DOIs
Publication statusPublished - Jan 1 1993

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Keywords

  • apparent amniogenic limb deficiency
  • case- control study
  • congenital limb deficiency
  • lower socioeconomic status
  • preterm birth
  • sporadic occurrence

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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