Study of inflammatory responses to crocidolite and basalt wool in the rat lung

Zoltán Adamis, Tibor Kerényi, Koichi Honma, Márta Jäckel, Erzsébet Tátrai, György Ungváry

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The subacute effects of crocidolite and basalt wool dusts were studied by means of biochemical, morphological, and histological methods 1 and 3 mo after intrabronchial instillation. The cell count, protein and phospholipid contents, and lactate dehydrogenase (LDH) activity were determined in the bronchoalveolar lavage (BAL). Both types of fibers induced a prolonged inflammatory reaction in the lung. All the parameters studied in the experimental groups were more markedly elevated after 3 too. Relative to the control, the protein and LDH values were increased three- to fivefold, the phospholipid content twofold, and the number of free cells in the BAL exceeded the control level up to ninefold. The inflammatory responses to crocidolite and basalt wool in the lung did not differ significantly. In spite of this, basalt wool is recommended as an asbestos substitute, as the use of this man-made fiber may result in a significantly lower release of dust than that from crocidolite.

Original languageEnglish
Pages (from-to)409-415
Number of pages7
JournalJournal of Toxicology and Environmental Health - Part A
Volume62
Issue number5
DOIs
Publication statusPublished - Mar 9 2001

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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