Study of in vitro antimicrobial and antiproliferative activities of selected Saharan plants

Ionut F. Palici, Erika Liktor-Busa, I. Zupkó, Blaise Touzard, Mohamed Chaieb, E. Urbán, J. Hohmann

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of the present study was the evaluation of the antimicrobial and antiproliferative activities of selected Saharan species, which are applied in the traditional medicine but not studied thoroughly from chemical and pharmacological point of view. The studied plants, namely Anthyllis henoniana, Centropodia forskalii, Cornulaca monacantha, Ephedra alata var. alenda, Euphorbia guyoniana, Helianthemum confertum, Henophyton deserti, Moltkiopsis ciliata and Spartidium saharae were collected from remote areas of North Africa, especially from the Tunisian region of Sahara. After drying and applying the appropriate extraction methods, the plant extracts were tested in antimicrobial screening assay, performed on 19 Gram-positive and -negative strains of microbes. The inhibition zones produced by plant extracts were determined by disc-diffusion method. Remarkable antibacterial activities were exhibited by extracts of Ephedra alata var. alenda and Helianthemum confertum against B. subtilis, M. catarrhalis and methicillin-resistant and non-resistant S. aureus. Minimum inhibitory concentrations of these two species were also determined. Antiproliferative effects of the extracts were evaluated against 4 human adherent cell lines (HeLa, A431, A2780 and MCF7). Notable cell growth inhibition was found for extract of Helianthemum confertum and Euphorbia guyoniana. Our results provided data for selection of some plant species for further detailed pharmacological and phytochemical examinations.

Original languageEnglish
Pages (from-to)385-394
Number of pages10
JournalActa Biologica Hungarica
Volume66
Issue number4
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Cistaceae
plant extract
Plant Extracts
Ephedra
Euphorbia
Northern Africa
traditional medicine
Methicillin
Phytochemicals
Cell growth
extraction method
Ciliophora
Pharmacology
Medicine
Assays
Drying
Screening
Methicillin Resistance
Cells
Microbial Sensitivity Tests

Keywords

  • Antibacterial activity
  • Antiproliferative activity
  • Ephedra alata var. alenda
  • Helianthemum confertum
  • Saharan plants

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

Cite this

Study of in vitro antimicrobial and antiproliferative activities of selected Saharan plants. / Palici, Ionut F.; Liktor-Busa, Erika; Zupkó, I.; Touzard, Blaise; Chaieb, Mohamed; Urbán, E.; Hohmann, J.

In: Acta Biologica Hungarica, Vol. 66, No. 4, 01.12.2015, p. 385-394.

Research output: Contribution to journalArticle

Palici, Ionut F. ; Liktor-Busa, Erika ; Zupkó, I. ; Touzard, Blaise ; Chaieb, Mohamed ; Urbán, E. ; Hohmann, J. / Study of in vitro antimicrobial and antiproliferative activities of selected Saharan plants. In: Acta Biologica Hungarica. 2015 ; Vol. 66, No. 4. pp. 385-394.
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