Study of histamine effects on phagocytosis and enzyme secretion of Tetrahymena pyriformis

Z. Darvas, B. Madarasz, V. László

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. The biogenic amine histamine develops effects not only in mammalian cells and tissues but in ciliated unicellular Tetrahymena as well. In addition to binding and internalization of labelled histamine, low concentrations can stimulate the phagocytosis of cells in inorganic salt solution. 2. In inorganic solution Tetrahymena cells secrete acid hydrolases to the medium. High concentration of histamine (10 mM) decreases the secretion of three investigated acid hydrolases in a different manner. We think that in this process the primary determinant is the alkaline character of histamine. 3. The effect of histamine on phagocytosis differs from the effect on secretion since the low, physiological concentration of histamine stimulates phagocytosis, the higher concentrations inhibit it. In the background of these effects possibly the hormone character is dominant. It is supported by the fact that histamine antagonists influence the process differently.

Original languageEnglish
Pages (from-to)325-334
Number of pages10
JournalActa Biologica Hungarica
Volume50
Issue number4
Publication statusPublished - 1999

Fingerprint

Histamine Agents
Tetrahymena pyriformis
histamine
phagocytosis
Phagocytosis
secretion
Histamine
enzyme
Enzymes
Tetrahymena
enzymes
Hydrolases
hydrolases
inorganic salt
acid
Cytophagocytosis
Acids
Biogenic Amines
antihistamines
Histamine Antagonists

Keywords

  • Acid hydrolases
  • Histamine
  • Phagocytosis
  • Tetrahymena

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Study of histamine effects on phagocytosis and enzyme secretion of Tetrahymena pyriformis. / Darvas, Z.; Madarasz, B.; László, V.

In: Acta Biologica Hungarica, Vol. 50, No. 4, 1999, p. 325-334.

Research output: Contribution to journalArticle

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