Study of factors affecting the antigen structure of the donor kidney - I. Interpretation of the relationship between periodate pretreatment and the rejection phenomena of canine kidney allografts

B. Török, E. Rőth, I. Tóth, Gy Deák

Research output: Contribution to journalArticle

Abstract

Donor kidneys were preserved in a Collins-4 solution containing periodate in concentrations of 10-2 and 10-4 mole/l, respectively, in an attempt to oxidize the carbohydrate components of the antigen-carrying membrane surfaces and thus to influence the rejection phenomena exhibited by the allogeneic kidney. All kidneys were, however, rejected as a result of a hyperacute reaction indicating that periodate did not react with the hydrophobic membrane structures in vivo. Not only did the antigen thus remain unchanged but the vulnerability of other renal structures to the destructive effect of the killer cells also increased as a result of toxic damage.

Original languageEnglish
Pages (from-to)215-222
Number of pages8
JournalInternational Urology and Nephrology
Volume11
Issue number3
DOIs
Publication statusPublished - Sep 1979

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Allografts
Canidae
Kidney
Antigens
Membranes
Poisons
Carbohydrates
metaperiodate

ASJC Scopus subject areas

  • Urology
  • Nephrology
  • Geriatrics and Gerontology

Cite this

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AU - Rőth, E.

AU - Tóth, I.

AU - Deák, Gy

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