Study of diastereomeric thioureas formed with a new chiral derivatizing agent

M. Péter, A. Perjéssy, D. Loos, F. Fülöp

Research output: Contribution to journalArticle

1 Citation (Scopus)


(1S,2S)-1,3-Diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate ((S,S)-DANI) was recently introduced as a new chiral derivatizing agent for the enantioseparation of amino compounds. In the present study, diastereomeric derivatives of racemic amino acids were formed with (S,S)-DANI. The thioureas produced were distinguished by means of infrared spectroscopy, theoretical calculations and high-performance liquid chromatography. The differences observed between the corresponding diastereomers by the independent methods are considered to prove the applicability of the new reagent in the field of enantiomer separation.

Original languageEnglish
Pages (from-to)525-534
Number of pages10
Issue number6
Publication statusPublished - Dec 1 2000


  • High-performance liquid chromatography
  • Hydrogen-bonding
  • Indirect enantioseparation
  • Infrared spectroscopy
  • PM3 quantum chemistry method

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry

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