Abstract
(1S,2S)-1,3-Diacetoxy-1-(4-nitrophenyl)-2-propyl isothiocyanate ((S,S)-DANI) was recently introduced as a new chiral derivatizing agent for the enantioseparation of amino compounds. In the present study, diastereomeric derivatives of racemic amino acids were formed with (S,S)-DANI. The thioureas produced were distinguished by means of infrared spectroscopy, theoretical calculations and high-performance liquid chromatography. The differences observed between the corresponding diastereomers by the independent methods are considered to prove the applicability of the new reagent in the field of enantiomer separation.
| Original language | English |
|---|---|
| Pages (from-to) | 525-534 |
| Number of pages | 10 |
| Journal | Enantiomer |
| Volume | 5 |
| Issue number | 6 |
| Publication status | Published - Dec 1 2000 |
Keywords
- High-performance liquid chromatography
- Hydrogen-bonding
- Indirect enantioseparation
- Infrared spectroscopy
- PM3 quantum chemistry method
ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Organic Chemistry
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Péter, M., Perjéssy, A., Loos, D., & Fülöp, F. (2000). Study of diastereomeric thioureas formed with a new chiral derivatizing agent. Enantiomer, 5(6), 525-534.