Studies on the use of NE-4C embryonic neuroectodermal stem cells for targeting brain tumour

Kornél Demeter, Anita Zádori, Viktor A. Ágoston, E. Madarász

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Neural stem cells were suggested to migrate to and invade intracranial gliomas. In the presented studies, interactions of NE-4C embryonic neural stem cells were investigated with C6 and Gl261, LL and U87, glioblastoma cells or with primary astrocytes. Glioma-derived humoral factors did not influence the proliferation of stem cells. NE-4C-derived humoral factors did not alter the proliferation of Gl261 and U87 cells, but increased the mitotic activity of C6 cells and that of astrocytes. In chimera-aggregates, all types of glioma cells co-aggregated with astrocytes, but most of them segregated from stem cells. Complete intercalation of stem and tumour cells was detected only in chimera-aggregates of Gl261 glioma and NE-4C cells. If mixed suspensions of NE-4C and Gl261 cells were injected into the brain, stem cells survived and grew inside the tumour mass. NE-4C stem cells, however, did not migrate towards the tumour, if implanted near to Gl261 tumours established in the adult mouse forebrain. The observations indicate that not all types of stem cells could be used for targeting all sorts of brain tumours.

Original languageEnglish
Pages (from-to)331-342
Number of pages12
JournalNeuroscience Research
Volume53
Issue number3
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Embryonic Stem Cells
Brain Neoplasms
Stem Cells
Glioma
Astrocytes
Neural Stem Cells
Neoplasms
Neoplastic Stem Cells
Glioblastoma
Prosencephalon
Brain Stem
Suspensions

Keywords

  • Cellular interaction
  • Glioma
  • Implantation
  • Migration
  • NE-4C
  • Neural stem cell

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Studies on the use of NE-4C embryonic neuroectodermal stem cells for targeting brain tumour. / Demeter, Kornél; Zádori, Anita; Ágoston, Viktor A.; Madarász, E.

In: Neuroscience Research, Vol. 53, No. 3, 11.2005, p. 331-342.

Research output: Contribution to journalArticle

Demeter, Kornél ; Zádori, Anita ; Ágoston, Viktor A. ; Madarász, E. / Studies on the use of NE-4C embryonic neuroectodermal stem cells for targeting brain tumour. In: Neuroscience Research. 2005 ; Vol. 53, No. 3. pp. 331-342.
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