Studies on the Synthesis of 3‐Vinylcephalosporins

János Pitlik, G. Batta, F. Sztaricskai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Several novel cephalosporins 4–19 having substituted vinyl functionalities at C‐3 were synthesized. The title compounds were prepared by a short and simple reaction sequence starting from protected 7‐aminocephalosporanic acid derivatives 1–3 and involving cleavage with iodotrimethylsilane, phosphonium salt formation, and subsequent Wittig reaction. The effect of the substituents are also discussed.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalLiebigs Annalen der Chemie
Volume1992
Issue number9
DOIs
Publication statusPublished - 1992

Keywords

  • Cephalosporins
  • Cephems, 3‐alkenyl‐
  • Wittig reactions

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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