Several novel cephalosporins 4–19 having substituted vinyl functionalities at C‐3 were synthesized. The title compounds were prepared by a short and simple reaction sequence starting from protected 7‐aminocephalosporanic acid derivatives 1–3 and involving cleavage with iodotrimethylsilane, phosphonium salt formation, and subsequent Wittig reaction. The effect of the substituents are also discussed.
- Cephems, 3‐alkenyl‐
- Wittig reactions
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry