Studies on the specificity of human antibodies reacting with GP70 and P15 antigens of baboon endogenous (BaEV) and gibbon ape leukaemia (GaLV) viruses

F. Tóth, L. Vaczi, B. Szabo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antibodies reacting with gp70 and p15 antigens of baboon endogenous virus (BaEV) and gibbon ape leukaemia virus (GaLV) were detected by radioimmunoprecipitation (RIP) in blood plasma samples of patients with chronic granulocytic leukaemia, acute myeloid leukaemia and with potentially preleukaemic haematological disorders. Anti-gp70 antibodies were found more frequently than anti-p15 antibodies. Digestion of the carbohydrate part of gp70 antigens by glycosidase treatment abrogated the precipitation mediated by IgM antibodies, whereas that mediated by IgG antibodies was not markedly affected. Data suggest that antibodies detected in human plasma samples may have oncovirus specificity, but in a considerable part of cases they may have a heterophilic nature.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalActa Virologica
Volume28
Issue number3
Publication statusPublished - 1984

Fingerprint

Gibbon ape leukemia virus
Antibody Specificity
Papio
Viruses
Antigens
Antibodies
Anti-Idiotypic Antibodies
Glycoside Hydrolases
Retroviridae
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Immunoglobulin M
Digestion
Immunoglobulin G
Carbohydrates

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Studies on the specificity of human antibodies reacting with GP70 and P15 antigens of baboon endogenous (BaEV) and gibbon ape leukaemia (GaLV) viruses. / Tóth, F.; Vaczi, L.; Szabo, B.

In: Acta Virologica, Vol. 28, No. 3, 1984, p. 191-197.

Research output: Contribution to journalArticle

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