The incorporation and elimination of Na2S35O4 into the lymphatic organs has been studied. Though the greatest incorporation of sulfate occurred usually in lymph nodes and spleen, the most vigorous reaction following hormone treatment (cortisone) was observed in the thymus. On injection of cortisone in a single dose, the latter took up sulfate continuously, while the other two organs released sulfate in a similar way. This dynamic reaction of the thymus has been correlated by the authors with its mast cell producing activity and its participation in the metabolism of acid mucopolysaccharides.
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