Studies on the interaction of methomyl and ethanol in rats

M. Antal, M. Bedö, G. Constantinovits, K. Nagy, J. Szépvölgyi

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Abstract

The effects of feeding methomyl (200 mg/kg diet) and ethanol (10% aqueous solution) both separately and together were studied in R/Amsterdam rats. Response to the combined administration of the two agents produced evidence of some interactions, resulting in a decrease in growth in both male and female rats and an increase in the relative weights of the adrenals. Sex differences were apparent, however, in some of the responses to the combined treatment: only in the male rats were hepatic levels of triglyceride and free fatty acids increased and the cholinesterase activity of the brain decreased to a level significantly below those associated with administration of either agent separately, whereas in the females the relative weights of the kidneys and the fasting level of blood-glucose were increased.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalFood and Cosmetics Toxicology
Volume17
Issue number4
DOIs
Publication statusPublished - 1979

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ASJC Scopus subject areas

  • Toxicology

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