Studies on the conversion of thyroxine to 3,5,3′-triiodothyronine in normal and thyroidectomized chickens

P. Rudas, G. Pethes

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The possibility of conversion of l-thyroxine (T4) to l-3,5,3′-triiodothyronine (T3) and to 3,3′,5′-triiodothyronine (reverse-T3, r-T3) has been investigated in chickens. Reverse-T3 could not be detected in normal animals. Both thyroidectomized and normal animals were able to convert exogenous T4 to T3. The administration of propylthiouracyl blocked this conversion to a greater extent than had been expected from the data on mammals. The conversion ratio is higher than in any other species reported in the literature. Data suggest that, as a result of the adaptation of the peripheral deiodination, thyroidectomized animals were able to convert more T4 to T3 than were normal ones.

Original languageEnglish
Pages (from-to)154-161
Number of pages8
JournalGeneral and Comparative Endocrinology
Volume54
Issue number1
DOIs
Publication statusPublished - Apr 1984

    Fingerprint

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

Cite this