Studies on the antibodies to human herpesvirus type 6 among Hungarian patients with asymptomatic HIV infection

Csaba László Maródi, Anna Csiszár, Beatriz Sierra-Vazquez, Dario Di Luca, Éva Barabás, Károly Nagy, Joseph Ongrádi

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The occurrence and the possible role in promoting HIV infection by human herpesvirus type 6 (HHV-6) have not yet been revealed in Hungary. In different groups of patients, serum titre of IgM and IgG antibodies, as well as avidity of IgG were quantitated by indirect immunofluorescence and an enzyme-linked immunosorbent assay, using isolate U1102 of HHV-6 variant A as antigen. In 60% of HIV-seronegative adult controls, high avidity IgG antibodies were found in low titre suggesting childhood infection. In HIV- seronegative persons with high risk behaviour for HIV-infection, both IgM and low avidity IgG were frequently found in higher titre, representing either primary or frequent reinfections, or reactivation of latent HHV-6. In asymptomatic HIV-seropositive patients, high titre of high avidity IgG antibodies was predominant, proving virus infection in the near past. These results indicate the contribution of HHV-6 to immunosuppression prior to AIDS, predisposing the organism to HIV infection.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalPathology and Oncology Research
Issue number1
Publication statusPublished - Jan 1 1998



  • Asymptomatic HIV-1 infection
  • HHV-6
  • IgG avidity
  • IgM
  • Seroepidemiology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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