Studies on naphthyridines. Part 2 . Synthesis of 4‐substituted and 6‐substituted 1,6‐naphthyridin‐5(6H)‐ones

Mária Balogh, István Hermecz, Kálmán Simon, Levente Pusztay

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Ethyl 4‐substituted 2‐methyl‐5‐oxo‐5,6‐dihydro‐1,6‐naphthyridine‐3‐carboxylates 3a‐h were synthetized in a one‐step reaction from diethyl 2,6‐diraethylpyridine‐3,5‐dicarboxylates 1a‐h by aminomethinylation with 1,3,5‐triazine (2). The 6‐substitued derivatives 6a‐z,aa‐ff could be obtained from diethyl 2‐[2‐(dimethylamino)‐vinyl]‐6‐methylpyridine‐3,5‐dicarboxylate (4) either directly or via the isolated intermediate 2‐[2‐(arylamino)‐vinyl]pyridine compounds 5a‐i.

Original languageEnglish
Pages (from-to)1755-1769
Number of pages15
JournalJournal of Heterocyclic Chemistry
Issue number6
Publication statusPublished - Jan 1 1989


ASJC Scopus subject areas

  • Organic Chemistry

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