Studies on interferon production and interferon sensitivity of different strains of Newcastle disease virus

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Strains of Newcastle disease virus (NDV), which were good or poor inducers of interferon in chick cells, occurred in all virulence groups of this virus. Mesogenic and velogenic strains which killed the embryo rapidly were better interferon inducers in embryonated egg than were the lentogenic strains. Identical and low sensitivities to interferon were shown by an interferon inducing vaccine strain and a non inducing and highly virulent strain. Measurements made when various strains were used to infect either normal or interferon pre treated cells showed that the absence of interferon production was not due to the inhibitory effect of virus infection on cellular protein synthesis. It is suggested that infective NDV synthesizes two kinds of inhibitory protein during infection. One of these inhibits the synthesis of the interferon protein and in consequence the majority of strains do not induce interferon in chick cells. The second protein is induced mainly by mesogenic and velogenic strains and may be responsible for inhibiting cellular protein synthesis.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalJournal of General Virology
Volume21
Issue number2
DOIs
Publication statusPublished - Jan 1 1973

ASJC Scopus subject areas

  • Virology

Fingerprint Dive into the research topics of 'Studies on interferon production and interferon sensitivity of different strains of Newcastle disease virus'. Together they form a unique fingerprint.

  • Cite this