We have investigated the expression of several growth-related genes in the liver after partial hepatectomy in three experimental models: normal, Dexamethasone-pretreated, and hypophysectomized rats. Dexamethasone and hypophysectomy resulted in a delay in the peak of cell replication in 6 and 18 h, respectively, when compared to the normal animals. TGFα mRNA expression was shifted together with the DNA synthesis, but the expression of c-myc, c-fos, c-jun, HGF, TGFβ1, IL1β did not delay. This result suggests that liver-derived TGFα but not the other factors are important in the timing of the proliferative response after partial hepatectomy. (C) 2000 Academic Press.
|Number of pages||5|
|Journal||Biochemical and biophysical research communications|
|Publication status||Published - Jun 7 2000|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology