Studies on hepatic gene expression in different liver regenerative models

Peter Nagy, Hanne Cathrine Bisgaard, Janos Schnur, Snorri S. Thorgeirsson

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have investigated the expression of several growth-related genes in the liver after partial hepatectomy in three experimental models: normal, Dexamethasone-pretreated, and hypophysectomized rats. Dexamethasone and hypophysectomy resulted in a delay in the peak of cell replication in 6 and 18 h, respectively, when compared to the normal animals. TGFα mRNA expression was shifted together with the DNA synthesis, but the expression of c-myc, c-fos, c-jun, HGF, TGFβ1, IL1β did not delay. This result suggests that liver-derived TGFα but not the other factors are important in the timing of the proliferative response after partial hepatectomy. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)591-595
Number of pages5
JournalBiochemical and biophysical research communications
Volume272
Issue number2
DOIs
Publication statusPublished - Jun 7 2000

Keywords

  • 1L1β
  • HGF
  • Liver
  • Regeneration
  • TGF-α
  • TGF-β1
  • c-fos
  • c-jun
  • c-myc

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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