Studies on canine mammary tumours. II. Oestradiol and progesterone receptor binding capacity and histological type.

H. Boldizsár, T. Muray, I. Számel, O. Szenci, J. Csenki

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Abstract

Tissue samples taken from the mammary gland of 42 dogs (age: 6 to 12 years) were examined. Thirty-eight samples showed neoplasia: 36 were epithelial while the remaining 2 proved to be connective tissue tumours. Thirty-four % of the neoplasms were new benign tumours (most frequently adenoma and fibroadenoma) and 66% were malignant ones (mainly adenocarcinoma). The oestrogen receptor (ER) and progesterone receptor (PR) binding capacity was determined on 21 tissue samples using the method of EORTC (1980). The connective tissue tumours and non-tumourous tissues contained no sexual steroid receptor. 71.4% of all tissue samples contained receptors. 61.9% of the samples was ER+, 42.8% was PR+, 33.3% contained both receptors, 28.6% was only ER+ and 9.5% only PR+. The average ER and PR binding capacity was 120.3 (5.0-622.8) and 266.7 (92.3-475.0) fmol/mg cytosol protein, respectively. No difference in receptor positivity was demonstrable between the benign and the malignant tumours. PR negativity accompanied by ER positivity was more common in the case of benign tumours. ER binding capacity tended to be correlated with age: this correlation could be described with a hyperboloid regression curve (r = -0.5931; 0.06 > p > 0.05).

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalActa Veterinaria Hungarica
Volume40
Issue number1-2
Publication statusPublished - 1992

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Estradiol Receptors
mammary neoplasms (animal)
binding capacity
Progesterone Receptors
Canidae
Breast Neoplasms
neoplasms
dogs
Neoplasms
connective tissues
Connective Tissue
receptors
sampling
Fibroadenoma
Steroid Receptors
adenoma
Human Mammary Glands
adenocarcinoma
progesterone receptors
estrogen receptors

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Studies on canine mammary tumours. II. Oestradiol and progesterone receptor binding capacity and histological type. / Boldizsár, H.; Muray, T.; Számel, I.; Szenci, O.; Csenki, J.

In: Acta Veterinaria Hungarica, Vol. 40, No. 1-2, 1992, p. 89-97.

Research output: Contribution to journalArticle

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