Studies on calix(aza)crowns, I. Synthesis, alkylation reactions and comprehensive NMR investigation of capped calix[4]arenes

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Abstract

Calix[4]arenes capped by diamide bridges in 1,3-position on the lower rim were synthesized. Regioselective alkylations of compounds 2 afforded 3, 4 O- and N-alkylated derivatives. Comprehensive NMR investigations were made to reveal the conformation of calix(aza)crowns 2, 3, 4.

Original languageEnglish
Pages (from-to)9799-9812
Number of pages14
JournalTetrahedron
Volume53
Issue number28
DOIs
Publication statusPublished - Jul 14 1997

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Diamide
Alkylation
Crowns
Conformations
Nuclear magnetic resonance
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

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abstract = "Calix[4]arenes capped by diamide bridges in 1,3-position on the lower rim were synthesized. Regioselective alkylations of compounds 2 afforded 3, 4 O- and N-alkylated derivatives. Comprehensive NMR investigations were made to reveal the conformation of calix(aza)crowns 2, 3, 4.",
author = "I. Bitter and A. Gr{\"u}n and G{\'a}bor T{\'o}th and B. Bal{\'a}zs and L. Tőke",
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AU - Tőke, L.

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