Studies of the platelet filter test (shear dependent platelet aggregation) in patients with uncommon haemorrhagic disorders

Z. Boda, I. Tornai, K. Rak

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Platelets of anticoagulated whole blood forced at 40 mmHg through a fine filter are activated, aggregated and retained, so block the filter (platelet filter test, O'Brien JR, Salmon GP. Blood 1987; 1354-1361). Our clinical experiences with this simple and quick haemostasis test are summarized. Patients were investigated with different types of vWD (type-1 = 35, type-2A = 7, type-2B = 7, type-3 = 1), Glanzmann's thrombasthenia, congenital deficiency of cyclo-oxygenase, acquired Bernard-Soulier syndrome, FXII-, FXIII-deficiency and a control group. The cumulative drop count and the platelet retention were carefully measured during two phases of the filter test. Platelet count, bleeding time, vWF:Ag and vWF:Rcof activity were measured along with the platelet filter test. The filter was not blocked and the platelet retention was abnormally low in all patients with thrombasthenia, type-2a, type-2B, type-3 vWD. Treatment with 1-desamino-8-D-arginine-vasopressin (DDAVP) caused enhanced platelet retention in 16 patients with type-1 vWD. The test is simple, quick and cheap, has good reproducibility, and may be useful in clinical haemostasis laboratories for examination of high shear induced platelet functions.

Original languageEnglish
Pages (from-to)162-164
Number of pages3
JournalBlood Coagulation and Fibrinolysis
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 1 1996

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Keywords

  • Platelet filter test
  • Primary haemostasis
  • Shear
  • vWD

ASJC Scopus subject areas

  • Hematology

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